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Drug Class and Mechanism of Action of Prednisolone

Prednisolone is a corticosteroid group of drug. It modifies the immune response of the body to various conditions and also acts by reducing inflammation.

Therapeutic Uses of Prednisolone

Prednisolone (and other corticosteroids) is used in treatment of allergies, arthritis, breathing problems ( bronchial asthma), certain blood disorders, collagen diseases (lupus), certain eye diseases like keratitis, cancer (leukemia or blood cancer), endocrine or hormone problems (adreno-cortical insufficiency), intestinal problems like ulcerative colitis, swelling due to certain conditions, or skin conditions like psoriasis. It can also be used in many other conditions that your doctor determines.

Direction of use of Prednisolone

Take Prednisolone as per direction of your doctor or follow the instructions given in the label of the medicine for exact dosing. Take Prednisolone by mouth with water on full stomach or on empty stomach. The pill of Prednisolone should be swallowed as a whole without breaking, crushing or chewing it. Keep taking Prednisolone even if you feel better without missing a dose.

If You Miss a Dose of Prednisolone

If you miss a dose of Prednisolone, you should skip the missed dose and go back to your regular dosing schedule. Do not take double dose for missing a dose.

How to Store Prednisolone

Prednisolone should be stored at 77 degrees F or 25 degrees C. It can be stored briefly with out any problem between 59 and 86 degrees F (15 and 30 degrees C). Store it away from moisture, heat and light. Keep Prednisolone out of the reach of children. Do not store Prednisolone in your bathroom.

More Information About Prednisolone

Use Prednisolone for yourself and do not share it with others. If you do not get any result or your symptoms worsen, consult your doctor immediately.

Precautions to be Taken While Taking Prednisolone

Do not use Prednisolone if you have any of the following medical conditions and consult your doctor immediately:

  • If you have allergy to any of the ingredients of Prednisolone.
  • If you are scheduled to have a live or attenuated live vaccination like varicella vaccine.
  • If you have a systemic fungal infection, malaria, inflammation of the optic nerve, or herpes infection of the eyes or if you are taking mifepristone.

Important notes on Prednisolone:

  • Pregnancy and breast feeding: Do not take Prednisolone if you are pregnant. If you become pregnant, consult your doctor to discuss the benefits and risks of using Prednisolone while you are pregnant. Prednisolone is found in breast milk. If you are or will be breast-feeding while you use Prednisolone, discuss with your doctor if there is any possible risks to your baby.
  • Prednisolone may lower the ability of your body to fight infection or reduce your immunity, so you need to avoid contact with people who have colds or infections. Inform your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • If you have no history of suffering from chickenpox, shingles, or measles, avoid contact with patients with from chickenpox, shingles, or measles.
  • Prednisolone may affect growth rate of children and teenagers. They may need regular growth checks if they taking Prednisolone.
  • Use Prednisolone with caution in children as, they may be more sensitive to its effects.
  • Prednisolone may affect your blood sugar, if you are a diabetic patient. Check blood sugar levels regularly. Ask your doctor if you need to change the dose of your diabetes medicine if you have to take Prednisolone.
  • Inform your doctor or dentist that you take Prednisolone before you receive any medical care, dental care, emergency care, or any surgery.
  • Do not receive a live vaccine (like measles, mumps) while you are taking Prednisolone. Discuss with your doctor before you receive any live vaccine while on Prednisolone.
  • Lab tests, including adrenal function tests, should be performed while you are using Prednisolone. These tests may be used to monitor your condition or check for side effects. Keep all doctor and lab appointments.
  • If you are taking Prednisolone regularly and over a long period of time, you should carry an ID card at all times that says you take Prednisolone.

Possible Adverse Effects of Prednisolone

Like any medicine Prednisolone has some side effects. Some of the side effects are minor and common and some are uncommon but serious. If you get any common side effect and it becomes bothersome or persistent, you should consult your doctor. The following are common and minor side effects of Prednisolone:

  • Acne, headache, nausea, clumsiness, facial flushing, feeling of a whirling motion or vertigo, dizziness; general body discomfort, increased appetite, increased sweating, nervousness, sleeplessness, stomach upset etc.

If you experience any serious side effects of Prednisolone, you should get immediate medical attention. The serious side effects of Prednisolone are:

  • Severe allergic reactions (rash, hives; itching; difficulty in breathing; feeling of tightness in the chest; swelling of the mouth, face, lips, or tongue); severe nausea or severe vomiting, headache, black stool, tarry stools, vomit that looks like coffee grounds, easy bruising or bleeding; unusual weight gain, changes in body fat; changes in menstrual period; changes in skin color; chest pain, infection (sings of infections are fever, chills, sore throat); mental or mood changes (depression); muscle pain, weakness, or wasting; seizures, sudden severe dizziness; swelling of feet or legs; tendon or bone pain; thinning of skin; unusual skin sensation, vision changes or other eye problems.


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