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Crestor

Rosuvastatin

Drug Class and Mechanism of Action of Crestor

Crestor belongs to the class of so called HMG co-enzyme reductase inhibitors and is intended for lowering the level of LDL (low density lipoprotein), which is also referred to as ‘bad cholesterol’. At the same time, it increases the level of HDL (high density lipoprostatin), also known as ‘good cholesterol’.

Rosuvastatin’s mechanism of action lies in converting HMG co-enzyme reductase to mevalonate, which actually inhibits the production of ‘bad cholesterol’. It contributes to an increase in the number of hepatic LDL receptors and therefore speeds up catabolism of LDL. Research has shown that rosuvastatin is more potent than other statins that are commonly used for treatment of bad cholesterol issues.

Therapeutic Uses of Crestor

Crestor is used to treat cholesterol problems and therefore prevent many related diseases, such as excess weight, heart trouble, atherosclerosis, strokes, etc. This is one of the newest and most potent statins, and it has proven very effective in reducing bad cholesterol (hyperlipidemia).

For the most part, Crestor is prescribed as adjunct to diet for treatment of different types of hyperlipidemia, mixed dyslipidemia, hypertriglyceridemia, Type III hyperlipoproteinemia, homozygous familial hypercholesterolemia, and progressive atherosclerosis.

Direction of use of Crestor

Crestor is used as part of a complex treatment course, which should include specific diet and physical exercise. It is absolutely mandatory that the drug be used under the direction of a qualified physician. Treatment strategy depends on various factors, such as severity of case, your general physical condition, adverse reactions to drugs, if any, or other anti-cholesterol drugs, if any, used previously or shortly before you started taking Crestor.

Your doctor must always be aware of your physical condition. Should any side effects occur or the should the drug not be less effective than expected, stop using it and tell your doctor immediately about the issue.

The drug is administered orally, with or without food.

Dose of Crestor, if Missed

Dosage may vary from 5 to 50 mg each day. Most recommended starting dose is 5-10 mg, depending on the disease you are dealing with. In any event, starting dose must be determined by your doctor.

It is strongly recommended that you follow the dosage set by your doctor. If you have missed a dose, do not try to compensate by taking a double dose. If it is almost time to take your next scheduled dose, skip it and take it as scheduled.

Important! Asian people show twice higher concentration or rosuvastatin than other races! In order to avoid adverse reactions, twice smaller doses must be administered to Asians (Chinese, Japanese, etc.)

How to Store Crestor

Crestor must be stored in a cool and dry place at room temperature 20-25ºC (68-77ºF). Do not keep it in the bathroom. Make sure it is kept out of the reach of children. Do not expose the medicine to sunlight, high temperatures or moist. Do not store Crestor in the refrigerator. Do not take expired tablets. Do not flush expired Crestor down the toilet or throw it into the waste basket. To have it discarded safely, call your local waste disposal company or consult your health care provider.

More Information About Crestor

Rosuvastatin was approved by the FDA in August 2003 (Food and Drug Administration), for use in the USA. It was in 2008 that the medicine was tested and proven to be good for prevention of heart attacks and strokes. In two years following the trial, the drug was approved by the FDA for prevention of cardiovascular disorders.

Crestor is a potent HMG co-enzyme reductase inhibitor, and it interacts with some drugs. It is recommended to reduce the dose of Crestor if you are using cyclosporine, ritonavir, lopinavir, etc. Be careful if you are using or have recently used drugs that contain niacin (Niaspan, Advicor, Simcor, Niacor, etc.). Do not mix Crestor with gemfibrozil, fenofibrate or fenofibric acid (Lopid, Fenoglide, Triplix, Fibricor, etc.)

There are many medicines, which may cause your condition to get worse if used in combination with Crestor. Therefore, you must tell your doctor about all drugs you have used recently or are using currently, before you start using Crestor.

Precautions to be Taken While Taking Crestor

Crestor must not be used if you are allergic to rosuvastatin. It is contraindicated for people suffering liver or kidney problems. It should not be used by pregnant or breast-feeding women. This information must be taken seriously by women who are planning to become pregnant.

What’s more interesting yet noteworthy in terms of caution is the fact that Asian people (Japanese, Chinese) show about twice higher blood level of rosuvastatin than Europeans. That means higher possibility of overdose and side effects. This information must be included in the Dosage and Administration section, and it should not be overlooked by doctors. If you have Asian origin or any of your relatives do, please, take this information into account and start with a dose twice smaller than usually prescribed to non-Asian patients.

You should consult your doctor first if you have diabetes or thyroid gland problems.

Possible Adverse Effects

In some cases, Crestor may cause side effects, especially if you exceed your prescribed dose. Some patients experience muscular weakness and pain. This may indicate a breakdown of skeletal muscle tissue – a serious condition, which may cause kidney failure. If you notice any signs of this disorder, please, stop taking Crestor immediately and call your doctor.

If you have dark urine, irregular urination, loss of appetite, nausea and jaundice, most likely you are suffering hepatic insufficiency triggered by the drug. Please, stop taking the drug and seek emergency assistance.

Less serious reactions include headache, dry mouth, nausea, mild muscle pain, diarrhea/constipation, etc. If you have any of these, please, tell your doctor about it, so he/she will change the dose or prescribe a less potent medicine.

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